Английская Википедия:HSPB7

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Шаблон:Short description Шаблон:Infobox gene Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.[1],.[2] HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da.[3] HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins.[4] HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13.[5]

Expression and molecular function

HSPB7 is widely expressed throughout the body and its highest expression is observed in the cardiac tissue [4],.[6] HSPB protein family, including HSPB7, act protectively on aggregation of several proteins containing an extended polyglutamine (polyQ) stretch that are linked to a variety of neurodegenerative diseases.[7] Among these proteins, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of chaperones.[7] In addition, HSPB7 protein contains a HSP20 domain and strongly interacts with the chaperone protein 14-3-3.[5] An interaction with the 14-3-3 protein is a common molecular feature between HSPB7 and SRARP proteins [5],[8]

Role in cardiomyopathy and Cancer

HSPB7 has cardiac protective functions and mutations in this gene leads to cardiomyopathies.[7] It has been suggested that HSPB7 cardioprotective function is mediated by facilitating sarcomeric proteostasis.[9] Furthermore, HSPB7 is widely inactivated in malignancies by copy-number loss and epigenetic silencing and the overexpression of this protein results in a tumor suppressor function in multiple cancer cell lines[5],.[10] The overexpression of HSPB7 and its gene pair SRARP lead to a reduction in the relative phosphorylation and/or expression of Akt and ERK in cancer cells.[5] In addition, it has been suggested that HSBP7 is regulated by p53 tumor suppressor in renal cell carcinoma.[10]

Approved Symbol HSPB7
Approved Name Heat shock protein family B (small) member 7
HGNC ID HGNC:5249
Previous name heat shock 27kD protein family, member 7 (cardiovascular)
Alias Symbols cvHSP
Chromosome location 1p36.13
Ensembl ENSG00000173641
UniProt Q9UBY9
NCBI Gene 27129
RefSeq NM_014424
UCSC uc001axo.2
Protein Sequence HSPB7 Protein Sequence (Ensembl)
Wikidata Q18038659
PubMed HSPB7 PubMed References

References

Шаблон:Reflist

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  1. ↑ Шаблон:Cite web
  2. ↑ Шаблон:Cite web
  3. ↑ Шаблон:Cite web
  4. ↑ 4,0 4,1 Шаблон:Cite journal
  5. ↑ 5,0 5,1 5,2 5,3 5,4 Шаблон:Cite journal
  6. ↑ Шаблон:Cite journal
  7. ↑ 7,0 7,1 7,2 Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
  10. ↑ 10,0 10,1 Шаблон:Cite journal
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