Английская Википедия:HU-210
Шаблон:Short description Шаблон:Drugbox HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol[1] by a group led by Raphael Mechoulam at the Hebrew University.[2][3][4] HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.[5] HU-210 has a binding affinity of 0.061 nM at CB1 and 0.52 nM at CB2 in cloned human cannabinoid receptors[6] compared to delta-9-THC of 40.7 nM at CB1. [7] HU-210 is the (–)-1,1-dimethylheptyl analog of 11-hydroxy- Δ8- tetrahydrocannabinol; in some references it is called 1,1-dimethylheptyl- 11-hydroxytetrahydrocannabinol. The abbreviation "HU" stands for Hebrew University.
Effects and research
HU-210, the (–) enantiomer of 11-OH-D8-THC-DMH, has almost all of the cannabinoid activity, while the (+) enantiomer, known as HU-211, is inactive as a cannabinoid and instead acts as an NMDA antagonist having neuroprotective effects.[8][9]
HU-210 has an oral LD50 of 5,000 mg/kg in rats and 14,200 mg/kg in rabbits.[10] HU-210 has an LDLO (Lowest Lethal Dose amount) of 143 mg/kg in humans.[10] Delta-8-THC LD50 has not been confirmed. In a 1973 study monkeys and dogs given 9,000 mg/kg of delta-8-THC was nonlethal.[11][12]
Chemistry
HU-210 is the enantiomer of HU-211 (dexanabinol). The original synthesis of HU-210 is based on an acid-catalyzed condensation of (–)-Myrtenol and 1,1-Dimethylheptylresorcinol (3,5-Dihydroxy-1-(1,1-dimethylheptyl)benzol).[1]
Legal status
HU-210 is not listed in the schedules set out by the United Nations' Single Convention on Narcotic Drugs from 1961 nor their Convention on Psychotropic Substances from 1971,[13] so the signatory countries to these international drug control treaties are not required by said treaties to control HU-210.
New Zealand
HU-210 is banned in New Zealand as of 8 May 2014.[14]
United States
HU-210 is not explicitly listed in the list of scheduled controlled substances in the USA.[15] A brief profile of HU-210 written and published by the Drug Enforcement Administration (DEA) in 2009, but removed in later years, stated that HU-210 is a Schedule I controlled substance under the Controlled Substances Act due to being similar to THC.[16] A version of the document (updated in 2013), now in PDF form, exists on the DEA Office of Diversion Control's website.[17] In that PDF, DEA reasserts that HU-210 is a Schedule I substance. DEA currently considers HU-210 a Schedule I controlled substance under the umbrella of ‘tetrahydrocannabinols’. HU-210’s DEA No. is 7370; the same number assigned to dronabinol and synthetic Delta-8-THC.[18]
Alabama
HU-210 is a Schedule I controlled substance in Alabama.[19] Шаблон:Quote
Florida
HU-210 is a Schedule I controlled substance, categorized as a hallucinogen, making it illegal to buy, sell, or possess in the state of Florida without a license.[20] Шаблон:Cquote
Vermont
Effective January 1, 2016, HU-210 is a regulated drug in Vermont designated as a "Hallucinogenic Drug."[21]
Other HU Cannabinoids
See also
References
Further reading
Шаблон:Cannabinoids Шаблон:Hallucinogens Шаблон:Cannabinoidergics
- ↑ 1,0 1,1 Шаблон:Cite journal
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- ↑ 10,0 10,1 Шаблон:Cite web
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