Afifi Pasha was born in 1885 or 1886.[1] There is another report stating that he was born in Cairo in 1886.[2] He was a physician before entering diplomacy. According to a profile by Dorothy Thompson, he became "one of the most famous specialists in the Arab world."[3]
Afifi Pasha was the minister of foreign minister between June 1928 and October 1929 in the cabined of Mohamed Mahmoud Pasha.[2] Later he served as the Misr Bank's president and Ambassador of Egypt to the United Kingdom.[4] He held the presidency of the United Nations Security Council from 17 April to 16 May 1946.[5] In December 1951 he was appointed to be the chief of Farouk of Egypt's royal cabinet. The move sparked rumors that Mostafa El-Nahas's government had resigned. These were denied. In the early days of holding the post he advocated increasing Egyptian ties to western nations such as Britain and the United States.[4] The appointment was met with at least three protests across Egypt.[6]
Afifi Pasha was the recipient of the Grand Cordon of the Order of Ismail.[2] In 2015 it was reported that his villa in Alexandria was set for demolition.[10]