Английская Википедия:Homofenazine

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Шаблон:Short description Шаблон:For Шаблон:Infobox drug Homofenazine is an antipsychotic drug of the phenothiazines class.[1] It was synthesized by Wilhelm Schuler and colleagues at Degussa.[2][3] In 1966, it was released in Belgium under the brand name Pasaden.[4] At some point, it was quietly discontinued and is no longer marketed.Шаблон:Citation needed

Synthesis

Файл:Homofenazine synthesis.svg
Thieme Patents (Ex 5&6):[5][6]

The alkylation between 2-(Trifluoromethyl)Phenothiazine [92-30-8] (1) and 1-(3-bromopropyl)-1,4-diazepane (2) led to 10-[3-(1,4-diazepan-1-yl)propyl]-2-(trifluoromethyl)phenothiazine, CID:110174391 (3). Further alkylation with 2-Chloroethanol [107-07-3] (4) completed the synthesis of homofenazine (5).

References

Шаблон:Reflist

  1. Ошибка цитирования Неверный тег <ref>; для сносок Martindale2007 не указан текст
  2. Шаблон:Cite book
  3. Шаблон:Cite patent.
  4. Ошибка цитирования Неверный тег <ref>; для сносок Schlesser не указан текст
  5. Schuler Wilhelm Alfons, Beschke Helmut, Schlichtegroll Ansgar Von, Шаблон:US patent (1962 to Degussa).
  6. Helmut Beschke, Schuler Dr Wilhelm Alfons, DE1445648A1 (1968 to Degussa).