Английская Википедия:Human maximisation test

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The Human maximisation test (HMT) is a test method for testing for contact allergens. It was first developed by Albert Kligman in 1966[1] and updated by Kligman and William Epstein in 1975.[2] The first paper appeared 1966[3] and was a citation classic in 1985.[4]

The test uses human medical volunteers (usually 25) and sodium laureth sulphate to maximise. Because of the potentially large human reaction, it is generally not considered ethical to use today.[5] It does not have a guideline under the OECD Guidelines for the Testing of Chemicals. It has been compared with the murine local lymph node assay[6][7]

See also

References

Шаблон:Reflist

  1. The Identification of Contact Allergens by Human Assay III. The Maximization Test: A Procedure for Screening and Rating Contact Sensitizers http://www.nature.com/jid/journal/v47/n5/abs/jid1966160a.html
  2. Шаблон:Cite journal
  3. Шаблон:Cite journal
  4. http://garfield.library.upenn.edu/classics1985/A1985AUG6800001.pdf Шаблон:Bare URL PDF
  5. Шаблон:Cite web
  6. DA Basketter, EW Scholes, I Kimber (1994). The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food and Chemical Toxicology, 1994 - Elsevier
  7. Шаблон:Cite journal