Английская Википедия:Human monocytotropic ehrlichiosis

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Шаблон:Infobox medical condition (new) Human monocytotropic ehrlichiosis[1] is a form of ehrlichiosis associated with Ehrlichia chaffeensis.[2] This bacterium is an obligate intracellular pathogen affecting monocytes and macrophages.[3]

Symptom and signs

The most common symptoms are fever, headache, malaise, and muscle aches (myalgia). Compared to human granulocytic anaplasmosis, rash is more common.[4] Laboratory abnormalities include thrombocytopenia, leukopenia, and elevated liver tests.Шаблон:Citation needed

The severity of the illness can range from minor or asymptomatic to life-threatening. CNS involvement may occur. A serious septic or toxic shock-like picture can also develop, especially in patients with impaired immunity.[5]

Cause

This disease is known to be caused by tick bites.[6]

Diagnosis

Tick exposure is often overlooked. For patients living in high-prevalence areas who spend time outdoors, a high degree of clinical suspicion should be employed.Шаблон:Citation needed Ehrlichia serologies can be negative in the acute period. Polymerase chain reaction is therefore the laboratory diagnostic tool of choice.[7]

Treatment

If ehrlichiosis is suspected, treatment should not be delayed while waiting for a definitive laboratory confirmation, as prompt doxycycline therapy has been associated with improved outcomes.[8] Doxycycline is the treatment of choice.Шаблон:Cn

Presentation during early pregnancy can complicate treatment.[9] Rifampin has been used in pregnancy and in patients allergic to doxycycline.[10]

Epidemiology

In the US, human monocytotropic ehrlichiosis occurs across the south-central, southeastern, and mid-Atlantic states, regions where both the white-tailed deer (Odocoileus virginianus) and Lone Star ticks (Amblyomma americanum) thrive.Шаблон:Citation needed

Human monocytotropic ehrlichiosis occurs in California in Ixodes pacificus ticks and in Dermacentor variabilis ticks.[11] Nearly 600 cases were reported to the CDC in 2006. In 2001–2002, the incidence was highest in Missouri, Tennessee, and Oklahoma, as well as in people older than 60.[12]

See also

References

Шаблон:Reflist

External links

Шаблон:Medical resources

Шаблон:Bacterial diseases Шаблон:Tick-borne diseases Шаблон:Bacterial cutaneous infections