Английская Википедия:ID1
Шаблон:Short description Шаблон:About Шаблон:Infobox gene DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.[1][2]
Function
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors.[1] The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts.[1] This protein may play a role in cell growth, senescence, and differentiation.[3][4][5] Two transcript variants encoding different isoforms have been found for this gene.[6]
Interactions
ID1 has been shown to interact weakly with MyoD[1][7][8][9][10][11][12] but very tightly with ubiquitously expressed E proteins.[13] E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism. Other interacting partners include CASK.[14]
Clinical significance
ID1 can be used to mark endothelial progenitor cells which are critical to tumor growth and angiogenesis.[15][16] Targeting ID1 results in decreased tumor growth.[17][18] ID1 has been shown to be targeted by cannabidiol in certain gliomas and breast cancers.[19][20]
See also
References
Further reading
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External links
Шаблон:Transcription factors Шаблон:NLM content
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