Английская Википедия:Ibogaline

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Ibogaline is an alkaloid found in Tabernanthe iboga along with the related chemical compounds ibogaine, ibogamine, and other minor alkaloids. It is a relatively smaller component of Tabernanthe iboga root bark total alkaloids (TA) content. It is also present in Tabernaemontana species such as Tabernaemontana australis[1] which shares similar ibogan-biosynthetic pathways. The percentage of ibogaline in T. iboga root bark is up to 15% TA with ibogaine constituting 80% of the alkaloids and ibogamine up to 5%.[2][3]

Chemistry

Derivatives

Kisantine and Gabonine are thought to be ibogaline's oxidation byproducts.[4]

Adverse effect

In rodents, ibogaline induces more body tremor and ataxia compared to ibogaine and ibogamine.[5] Among a series of iboga and harmala alkaloids evaluated in rats, the study authors found the following order of potency in causing tremors:[5]

A subsequent study confirmed these findings.[6]

See also

References

Шаблон:Reflist