Английская Википедия:Interferon gamma receptor 1

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Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox gene Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.[1][2][3]

Function

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.[1]

Interactions

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[4][5]

Mutations

Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections.[6][7] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.[8][9]

See also

References

Шаблон:Reflist

Further reading

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External links

Шаблон:PDB Gallery Шаблон:Clusters of differentiation Шаблон:Cytokine receptors Шаблон:Cytokine receptor modulators

Шаблон:NLM content Шаблон:Membrane-protein-stub