Английская Википедия:International System for Human Cytogenomic Nomenclature

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The International System for Human Cytogenomic Nomenclature (previously International System for Human Cytogenetic Nomenclature), ISCN in short, is an international standard for human chromosome nomenclature, which includes band names, symbols and abbreviated terms used in the description of human chromosome and chromosome abnormalities.

The ISCN has been used as the central reference among cytogeneticists since 1960.[1][2]

Файл:Three chromosomal abnormalities with ISCN nomenclature.png
Three chromosomal abnormalities with ISCN nomenclature, with increasing complexity: (A) A tumour karyotype in a male with loss of the Y chromosome, (B) Prader–Willi Syndrome i.e. deletion in the 15q11-q12 region and (C) an arbitrary karyotype that involves a variety of autosomal and allosomal abnormalities.[3]
Файл:Human karyotype with bands and sub-bands.png
Human karyotype with annotated bands and sub-bands as used for the nomenclature of chromosome abnormalities. It shows dark and white regions as seen on G banding. Each row is vertically aligned at centromere level. It shows 22 homologous autosomal chromosome pairs, both the female (XX) and male (XY) versions of the two sex chromosomes, as well as the mitochondrial genome (at bottom left). Шаблон:Further

Abbreviations of this system include a minus sign (-) for chromosome deletions, and del for deletions of parts of a chromosome.[4]

Revision history

See also

References

Шаблон:Reflist

External links

Шаблон:Chromosome genetics

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  1. ↑ Slovak M.L., Theisen A., Shaffer L.G. (2013) "Human Chromosome Nomenclature: An Overview and Definition of Terms." In: Gersen S., Keagle M. (eds) The Principles of Clinical Cytogenetics. Springer, New York, NY Шаблон:Doi
  2. ↑ Шаблон:Cite journal
  3. ↑ Шаблон:Cite journal
    - "This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/)"
  4. ↑ Шаблон:Cite web
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