Английская Википедия:Isobucaine

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Isobucaine is a local anesthetic.[1]

Synthesis

Файл:Isobucaine synthesis.svg
Synthesis:[2]

The reductive amination between aminomethyl propanol (1) and isobutanal [78-84-2] (2) afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamine, CID:18315986 (3). Acylation of the amine with benzoyl chloride [98-88-4] hypothetically goes initially to the amide (4'). The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine (5).

See also

References

Шаблон:Reflist

Шаблон:Local anesthetics

Шаблон:Organic-compound-stub