Английская Википедия:Isochorismatase

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Шаблон:Infobox enzyme In enzymology, an isochorismatase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

isochorismate + H2O <math>\rightleftharpoons</math> 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Thus, the two substrates of this enzyme are isochorismate and H2O, whereas its two products are 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is isochorismate pyruvate-hydrolase. Other names in common use include 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, and 2,3-dihydroxy-2,3-dihydrobenzoic synthase. This enzyme participates in the biosynthesis of siderophore group (nonribosomal).

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.

References

Шаблон:Reflist

Шаблон:Ether bond hydrolases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:Hydrolase-stub