Английская Википедия:(R)-2-hydroxyacid dehydrogenase

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Шаблон:Short description Шаблон:Infobox enzyme In enzymology, a (R)-2-hydroxyacid dehydrogenase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

(2R)-3-sulfolactate + NAD(P)Шаблон:Sup <math>\rightleftharpoons</math> 3-sulfopyruvate + NAD(P)H + HШаблон:Sup

The 3 substrates of this enzyme are (2R)-3-sulfolactic acid, [[nicotinamide adenine dinucleotide|NADШаблон:Sup]], and [[nicotinamide adenine dinucleotide phosphate|NADPШаблон:Sup]], whereas its 4 products are 3-sulfopyruvic acid, NADH, NADPH, and [[hydrogen ion|HШаблон:Sup]]. This enzyme is important in the metabolism of archaea, particularly their biosynthesis of coenzymes such as coenzyme M, tetrahydromethanopterin and methanofuran.[1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NADШаблон:Sup or NADPШаблон:Sup as acceptor. The systematic name of this enzyme class is (R)-2-hydroxyacid:NAD(P)Шаблон:Sup oxidoreductase. Other names in common use include (R)-sulfolactate:NAD(P)Шаблон:Sup oxidoreductase, L-sulfolactate dehydrogenase, ComC, and (R)-sulfolactate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Шаблон:PDB link.

References

Шаблон:Reflist

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Шаблон:1.1.1-enzyme-stub