Английская Википедия:(S)-canadine synthase

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Шаблон:Short description Шаблон:Infobox enzyme In enzymology, a (S)-canadine synthase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

(S)-tetrahydrocolumbamine + NADPH + HШаблон:Sup + OШаблон:Sub <math>\rightleftharpoons</math> (S)-canadine + NADPШаблон:Sup + 2 HШаблон:SubO

The 4 substrates of this enzyme are (S)-tetrahydrocolumbamine, NADPH, [[hydrogen ion|HШаблон:Sup]], and [[oxygen|OШаблон:Sub]], whereas its 3 products are Canadine, [[nicotinamide adenine dinucleotide phosphate|NADPШаблон:Sup]], and [[water|HШаблон:SubO]].

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with OШаблон:Sub as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from OШаблон:Sub with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). Other names in common use include (S)-tetrahydroberberine synthase, and (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming). This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, heme-thiolate(P-450).

References

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