Английская Википедия:3-dehydrosphinganine reductase

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Шаблон:Short description Шаблон:Infobox enzyme Шаблон:Infobox gene 3-dehydrosphinganine reductase (Шаблон:EC number) also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the KDSR gene.[1][2][3][4][5]

Function

3-dehydrosphinganine reductase catalyzes the chemical reaction:

sphinganine + NADP+ <math>\rightleftharpoons</math> 3-dehydrosphinganine + NADPH + H+

Thus, the two substrates of this enzyme are sphinganine and NADP+, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in sphingolipid metabolism.

Tissue distribution

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue.

Clinical significance

FVT1 shows a high rate of transcription in some T cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.[5]

References

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External links

Further reading

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