Английская Википедия:3-hydroxyacyl-CoA dehydrogenase
Шаблон:Short description Шаблон:See also Шаблон:Infobox enzyme Шаблон:Protein In enzymology, a 3-hydroxyacyl-CoA dehydrogenase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction
- (S)-3-hydroxyacyl-CoA + NAD+ <math>\rightleftharpoons</math> 3-oxoacyl-CoA + NADH + H+
Thus, the two substrates of this enzyme are (S)-3-hydroxyacyl-CoA and NAD+, whereas its 3 products are 3-oxoacyl-CoA, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.
Isozymes
In humans, the following genes encode proteins with 3-hydroxyacyl-CoA dehydrogenase activity:
- HADH – Hydroxyacyl-Coenzyme A dehydrogenase
- HSD17B10 – 3-Hydroxyacyl-CoA dehydrogenase type-2
- EHHADH – Peroxisomal bifunctional enzyme
- HSD17B4 – Peroxisomal multifunctional enzyme type 2
Function
3-Hydroxyacyl CoA dehydrogenase is classified as an oxidoreductase. It is involved in fatty acid metabolic processes. Specifically it catalyzes the third step of beta oxidation; the oxidation of L-3-hydroxyacyl CoA by NAD+. The reaction converts the hydroxyl group into a keto group.
The end product is 3-ketoacyl CoA.
Metabolic pathways
This enzyme participates in 8 metabolic pathways: Шаблон:Div col
- fatty acid elongation in mitochondria
- fatty acid metabolism
- valine, leucine and isoleucine degradation
- lysine degradation
- tryptophan metabolism
- benzoate degradation via coa ligation
- butanoate metabolism
- caprolactam degradation
Nomenclature
The systematic name of this enzyme class is (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase. Other names in common use include: Шаблон:Div col
- 1-specific DPN-linked beta-hydroxybutyric dehydrogenase
- 3-hydroxyacetyl-coenzyme A dehydrogenase
- 3-hydroxyacyl coenzyme A dehydrogenase
- 3-hydroxybutyryl-CoA dehydrogenase
- 3-hydroxyisobutyryl-CoA dehydrogenase
- 3-keto reductase
- 3-L-hydroxyacyl-CoA dehydrogenase
- 3beta-hydroxyacyl coenzyme A dehydrogenase
- beta-hydroxy acid dehydrogenase
- beta-hydroxyacyl CoA dehydrogenase
- beta-hydroxyacyl dehydrogenase
- beta-hydroxyacyl-coenzyme A synthetase
- beta-hydroxyacylcoenzyme A dehydrogenase
- beta-hydroxybutyrylcoenzyme A dehydrogenase
- beta-keto-reductase
- beta-ketoacyl-CoA reductase
- L-3-hydroxyacyl CoA dehydrogenase
- L-3-hydroxyacyl coenzyme A dehydrogenase
Structural studies
As of 20 January 2010, 22 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.
References
Шаблон:Reflist Шаблон:Refbegin
Шаблон:Alcohol oxidoreductases Шаблон:Lipid metabolism enzymes Шаблон:Enzymes Шаблон:Portal bar
