Английская Википедия:3-oxoacyl-(acyl-carrier-protein) reductase

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Шаблон:Short description Шаблон:Infobox enzyme In enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

3-oxoacyl-[acyl-carrier-protein](ACP) + NADPH + H+ <math>\rightleftharpoons</math> (3R)-3-hydroxyacyl-[acyl-carrier-protein](ACP) + NADP+
Файл:3-oxoacyl-ACP reductase reaction.svg

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group as hydride donor with NAD+ or NADP+ as hydride acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase. Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, 3-ketoacyl ACP reductase, NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase, and 3-oxoacyl-[ACP]reductase. This enzyme participates in fatty acid biosynthesis and polyunsaturated fatty acid biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.

References

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Шаблон:Alcohol oxidoreductases Шаблон:Lipid metabolism enzymes Шаблон:Enzymes Шаблон:Portal bar


Шаблон:1.1.1-enzyme-stub