Английская Википедия:3alpha-hydroxysteroid dehydrogenase (A-specific)

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Шаблон:Short description Шаблон:Infobox enzyme In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

androsterone + NAD(P)+ <math>\rightleftharpoons</math> 5alpha-androstane-3,17-dione + NAD(P)H + H+

The 3 substrates of this enzyme are androsterone, NAD+, and NADP+, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific).

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.

References

Шаблон:Reflist

Шаблон:Alcohol oxidoreductases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:1.1.1-enzyme-stub