Английская Википедия:Acadia Pharmaceuticals
Шаблон:Short description Шаблон:Infobox company
Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Sorrento Valley, San Diego, California.[1]
Product development
Nuplazid, a drug developed by Acadia in the late 1990s, "was designed to stimulate a subset of the brain’s serotonin receptors, or the proteins that govern memory, cognition and learning."[2] On April 29, 2016, the FDA approved Acadia's drug, Nuplazid, for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.[3] Nuplazid is the trade name for Acadia's proprietary molecule, pimavanserin, a selective serotonin inverse agonist preferentially targeting 5-HT2a receptors. Acadia had partnered with Biovail in the late-stage clinical testing of the drug, which showed trial failures as of 2009.[4][5][6]
Acadia is running multiple Phase 2 and Phase 3 trials with pimavanserin in several central nervous system conditions: dementia-related psychosis,[7] major depressive disorder,[8] schizophrenia inadequate response,[9] and schizophrenia negative symptoms.[10]
Шаблон:As of, Acadia was among several companies that licensed compounds from Genzyme's small-molecule compound library.[11]
In 2023, the FDA approved trofinetide (marketed as Daybue) for use in Rett syndrome.[12]
History
Acadia started in 1993 as Receptor Technologies, based in Winooski, Vermont.[13] In 1997, the company relocated all operations and management from Vermont to San Diego, California as a strategic move to garner partnerships with other biotechnology companies.[13] However, the company also had an office in Denmark, in which it received a crucial part of its early investments[13][14] from BankInvest,[14] under managing director Florian Schönharting,[15][16][17] Kommunernes Pensionsforsikring A/S[14] and Dansk Kapitalanlæg Aktieselskab[14] as well as private investor Lars Christiansen.[18][14] At the time, the company had fifty employees, fourteen of whom were in the Denmark office.[13] The focus of the company in its early years was on genetic screens for receptors, aiming to accelerate early stage drug discovery.[13]
The company planned to conduct an Initial public offering (IPO) consisting of 31.6% of the company in 2001, with the intention of raising Шаблон:US$ and listing on the NASDAQ exchange under the symbol ACAD.[19] At the time, Acadia and Allergan were collaborating on development of a treatment for glaucoma, and Allergan would retain a 6.3% ownership stake in Acadia after the IPO.[19] However, the company's IPO, which ultimately took place in May 2004,[6] did not fare as well as expected and netted only Шаблон:US$.[20] At the time, the company had five drugs in development and was running two in human trials.[21] The company had a subsequent round of stock offering in May 2007 which raised Шаблон:US$.[22]
In September 2020, Acadia Pharmaceuticals acquired clinical-stage biotechnology company CerSci Therapeutics.[23]
Corporate governance
In 2001, the company's chief executive officer at the time, Leonard R. Borrmann, left Acadia to lead Maret Pharmaceuticals.[24] He was succeeded by Uli Hacksell, who left Acadia to lead Cerecor at the beginning of 2016.[25]
References
Шаблон:Portal Шаблон:Authority control
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite news
- ↑ 6,0 6,1 Шаблон:Cite news
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite journal
- ↑ 13,0 13,1 13,2 13,3 13,4 Шаблон:Cite news
"Biotech", continuation of article, p. D2. - ↑ 14,0 14,1 14,2 14,3 14,4 Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ Шаблон:Citation
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite web
- ↑ 19,0 19,1 Шаблон:Cite news
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite news
- ↑ Шаблон:Cite news
- Английская Википедия
- Pharmaceutical companies of the United States
- Pharmaceutical companies established in 1993
- 1993 establishments in California
- Health care companies based in California
- Companies based in San Diego
- Companies listed on the Nasdaq
- Страницы, где используется шаблон "Навигационная таблица/Телепорт"
- Страницы с телепортом
- Википедия
- Статья из Википедии
- Статья из Английской Википедии