Английская Википедия:Adverum Biotechnologies
Шаблон:Infobox company Adverum Biotechnologies, formerly known as Avalanche Biotechnologies,[1] is a publicly traded[2] clinical stage gene therapy company located in Redwood City, California.[3] The company is targeting unmet medical needs for serious ocular and rare diseases, including wet age-related macular degeneration (wet AMD).[4]
History
Avalanche Biotechnologies was founded in 2006 by Tom Chalberg, Mark Blumenkranz, Mitchell Finer, and Steven Schwartz.Шаблон:Cn Avalanche went public through an IPO in 2014, raising $102 million.[5]
In 2015, co-founder Tom Chalberg stepped down as CEO following Phase IIa trial results that were labeled as "iffy".[6]
In May 2016, Avalanche acquired Annapurna Therapeutics and changed its name to Adverum Biotechnologies.[7] It also changed its ticker symbol on the Nasdaq exchange from AAVL to ADVM.[7] In October 2016, former Annapurna Therapeutics CEO Amber Salzman became CEO of Adverum.[8]
In May 2018, CEO Amber Salzman left Adverum, and Chief Medical Officer Athena Countouriotis resigned after less than one year in the job.[9] In October 2018, Leone Patterson was named the new CEO of Adverum.[10]
In September 2019, Adverum announced six-month data from the first cohort of its phase I trial.[11] The stock price dropped 50% due to investor concerns over deterioration of vision that these trial subjects suffered, as well as several reports of occular inflammation.[11]
In June 2020, Laurent Fischer replaced Patterson as CEO of Adverum.[12]
In January 2022, the FDA granted Orphan Drug Designation to Adverum's ADVM-062, developed as a single intravitreal administration for blue-cone monochromacy by delivering a functional copy of the OPN1LW gene.[13]
In September 2022, Adverum announced that its first patient was dosed in the LUNA phase 2 clinical trial; the trial evaluates development for the treatment of wet age-related macular degeneration.[14][15]
References
- Английская Википедия
- 2006 establishments in California
- American companies established in 2006
- Biotechnology companies established in 2006
- Biotechnology companies of the United States
- Companies listed on the Nasdaq
- Companies based in Redwood City, California
- Technology companies based in the San Francisco Bay Area
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