Английская Википедия:Bioelectrospray

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Bio-electrospraying is a technology that enables the deposition of living cells on various targets with a resolution that depends on cell size and not on the jetting phenomenon. It is envisioned that "unhealthy cells would draw a different charge at the needle from healthy ones, and could be identified by the mass spectrometer", with tremendous implications in the health care industry.[1]

The early versions of bio-electrosprays were employed in several areas of research, most notably self-assembly of carbon nanotubes.[2][3] Although the self-assembly mechanism is not clear yet, "elucidating electrosprays as a competing nanofabrication route for forming self-assemblies with a wide range of nanomaterials in the nanoscale for top-down based bottom-up assembly of structures."[4] Future research may reveal important interactions between migrating cells and self-assembled nanostructures. Such nano-assemblies formed by means of this top-down approach could be explored as a bottom-up methodology for encouraging cell migration to those architectures for forming cell patterns to nano-electronics, which are a few examples, respectively.[5]

After initial exploration with a single protein,[6] increasingly complex systems were studied by bio-electrosprays. These include, but are not limited to, neuronal cells,[7] stem cells,[8][9] and even whole embryos.[10][11] The potential of the method was demonstrated by investigating cytogenetic and physiological changes of human lymphocyte cells[12] as well as conducting comprehensive genetic, genomic and physiological state studies of human cells[13] and cells of the model yeast Saccharomyces cerevisiae.[14]

See also

References

Шаблон:Reflist