Английская Википедия:High-altitude cerebral edema

Шаблон:Infobox medical condition (new) High-altitude cerebral edema (HACE) is a medical condition in which the brain swells with fluid because of the physiological effects of traveling to a high altitude. It generally appears in patients who have acute mountain sickness and involves disorientation, lethargy, and nausea among other symptoms. It occurs when the body fails to acclimatize while ascending to a high altitude.

It appears to be a vasogenic edema (fluid penetration of the blood–brain barrier), although cytotoxic edema (cellular retention of fluids) may play a role as well. Individuals with the condition must immediately descend to a lower altitude or coma and death can occur. Patients are usually given supplemental oxygen and dexamethasone as well.

HACE can be prevented by ascending to heights slowly to allow the body more time to acclimatize. Acetazolamide also helps prevent the condition. Untreated patients usually die within 48 hours. Those who receive treatment may take weeks to fully recover. It is a rare condition, occurring in less than one percent of people who ascend to Шаблон:Convert. Although it was first described in 1913, little was known about the cause of the condition until MRI studies were performed in the 1990s.

Signs and symptoms

Early symptoms of HACE generally correspond with those of moderate to severe acute mountain sickness (AMS).Шаблон:Sfn Initial symptoms of HACE commonly include confusion, loss of consciousness,Шаблон:Sfn fever, ataxia,Шаблон:Sfn photophobia, rapid heart beat,Шаблон:Sfn lassitude, and an altered mental state.Шаблон:Sfn Those affected generally attempt to cease physical activities, regardless of their necessity for survival. Severe headaches develop and people lose the ability to sit up.Шаблон:Sfn Retinal venous dilation occurs in 59% of people with HACE.Шаблон:Sfn Rarer symptoms include brisk deep tendon reflexes, retinal hemorrhages, blurred vision, extension plantar reflexes, and ocular paralysis.Шаблон:Sfn Cranial nerve palsies occur in some unusual cases.Шаблон:Sfn

In the bestselling 1996 non-fiction book Into Thin Air: A Personal Account of the Mt. Everest Disaster, Jon Krakauer describes the effects of HACE upon Dale Kruse, a forty-four-year-old dentist and one of the members of Scott Fischer's team:
'Kruse was having an incredibly difficult time simply trying to dress himself. He put his climbing harness on inside out, threaded it through the fly of his wind suit, and failed to fasten the buckle; fortunately, Fischer and Neal Beidleman noticed the screwup before Kruse started to descend. "If he'd tried to rappel down the ropes like that," says Beidleman, "he would have immediately popped out of his harness and fallen to the bottom of the Lhotse Face." '"It was like I was very drunk," Kruse recollects. "I couldn't walk without stumbling, and completely lost the ability to think or speak. It was a really strange feeling. I'd have some word in my mind, but I couldn't figure out how to bring it to my lips. So Scott and Neal had to get me dressed and make sure my harness was on correctly, then Scott lowered me down the fixed ropes." By the time Kruse arrived in Base Camp, he says, "it was still another three or four days before I could walk from my tent to the mess tent without stumbling all over the place."'

Patients with HACE have an elevated white blood cell count, but otherwise their blood count and biochemistry are normal. If a lumbar puncture is performed, it will show normal cerebral spinal fluid and cell counts but an increase in pressure.Шаблон:Sfn In one study, CT scans of patients with HACE exhibited ventricle compression and low density in the cerebellum.Шаблон:Sfn Only a few autopsies have been performed on fatal cases of HACE;Шаблон:Sfn they showed swollen gyri, spongiosis of white matter, and compressed sulci. There was some variation between individuals, and the results may not be typical of HACE deaths.Шаблон:Sfn

Mechanism

Most people who travel to high altitudes acclimatize. Acclimatization precludes the development of HACE by maintaining adequate levels of cerebral oxygen.Шаблон:Sfn The primary cause of HACE is hypoxia (oxygen deprivation).Шаблон:Sfn This occurs after the body is exposed to a low-oxygen environment and before it acclimatizes. The rate of change from a normal oxygen environment and how little oxygen is in the new environment can be used to predict the chance of developing HACE.Шаблон:Sfn Prolonged exertion in low oxygen also causes serious hypocapnia, lower carbon dioxide in the bloodstream,Шаблон:Sfn which may play a role in HACE.Шаблон:Sfn These factors cause the brain to swell with fluid, resulting in severe impairment.Шаблон:Sfn If the swelling is untreated, it causes death by brain herniation.Шаблон:Sfn

The brain swelling is likely a result of vasogenic edema, the penetration of the blood–brain barrier by fluids.Шаблон:Sfn This process has been observed in MRI studies. Hypoxia increases extracellular fluid, which passes through the vasogenic endothelium in the brain. The leaking may be caused by increased pressure, or it may be caused by inflammation that makes the endothelium vulnerable to leaking.Шаблон:Sfn An MRI study found microhemorrhages in the corpus callosum of HACE patients,Шаблон:Sfn and hypoxia may also cause microvascular permeability.Шаблон:Sfn It has been hypothesized that vascular endothelial growth factor may cause the vascular permeability at the root of HACE.Шаблон:Sfn MRI scans of patients with HACE showed increased T2 in the corpus callosum, although grey matter was unchanged. This demonstrated that the blood-brain barrier was broken by cerebral blood vessels, thus interfering with white matter metabolism.Шаблон:Sfn Another study looked at the brains of people with HACE several months after their recovery; it showed hemosiderin deposits in the corpus callosum, evidence of vascular permeability.Шаблон:Sfn

While there is strong evidence that vasogenic edema plays a major role in HACE, cytotoxic edema, cellular retention of fluids, may contribute as well.Шаблон:Sfn Шаблон:Sfn Cytotoxic edema may be caused by the failure of cellular ion pumps, which results from hypoxia. Then intracellular sodium and osmolarity increase, and there is an influx of water that causes cellular swelling.Шаблон:Sfn Шаблон:Sfn After the failure of the ATPase pumps, free radicals form and cause damage that complicates the edema.Шаблон:Sfn Evidence against cytotoxic edema includes the high levels of hypoxemia (low bloodstream oxygen) needed to cause it.Шаблон:Sfn

It is not known why some are more vulnerable to HACE than others. One theory is that variations in brain size play a role, but the increase in brain volume from edema does not likely cause cranial vault impingement.Шаблон:Sfn The presence of large sulci indicate the condition may be influenced by the brain tightly fitting.Шаблон:Sfn Elevated intracranial pressure is generally accepted to be a late effect of HACE.Шаблон:Sfn Шаблон:Sfn High central venous pressure may also occur late in the condition's progression.Шаблон:Sfn

One study demonstrated that normal autorelation of cerebral blood flow does not cause HACE.Шаблон:Sfn What role the sympathetic nervous system plays in determining who gets HACE is unclear, but it may have an effect.Шаблон:Sfn

Another theory about the cause of HACE is that hypoxia may induce nitrous oxide synthase.Шаблон:Sfn Vasodilation is caused by the release of nitric oxide and adenosine.Шаблон:Sfn This in turn can increase vascular permeability and causes edema. This may combine with low levels of cytokines to cause HACE.Шаблон:Sfn

Diagnosis

Generally, high-altitude pulmonary edema (HAPE) or AMS precede HACE.Шаблон:Sfn In patients with AMS, the onset of HACE is usually indicated by vomiting, headache that does not respond to non-steroidal anti-inflammatory drugs, hallucinations, and stupor.Шаблон:Sfn Шаблон:Sfn In some situations, however, AMS progresses to HACE without these symptoms.Шаблон:Sfn HACE must be distinguished from conditions with similar symptoms, including stroke, intoxication, psychosis,Шаблон:Sfn diabetic symptoms, meningitis,Шаблон:Sfn or ingestion of toxic substances.Шаблон:Sfn It should be the first diagnosis ruled out when sickness occurs while ascending to a high altitude.Шаблон:Sfn

Prevention

HACE is generally preventable by ascending gradually with frequent rest days while climbing or trekking.Шаблон:Sfn Шаблон:Sfn Not ascending more than Шаблон:Convert daily and not sleeping at a greater height than Шаблон:Convert more than the previous night is recommended.Шаблон:Sfn The risk of developing HACE is diminished if acetazolamide or dexamethasone are administered.Шаблон:Sfn Generally, the use of acetazolamide is preferred, but dexamethasone can be used for prevention if there are side effects or contraindications.Шаблон:Sfn Some individuals are more susceptible to HACE than others,Шаблон:Sfn and physical fitness is not preventive.Шаблон:Sfn Age and sex do not by themselves affect vulnerability to HACE.Шаблон:Sfn

Treatment

Patients with HACE should be brought to lower altitudes and provided supplemental oxygen,Шаблон:Sfn and rapid descent is sometimes needed to prevent mortality.Шаблон:Sfn Early recognition is important because as the condition progresses patients are unable to descend without assistance.Шаблон:Sfn Dexamethasone should also be administered,Шаблон:Sfn although it fails to ameliorate some symptoms that can be cured by descending to a lower altitude.Шаблон:Sfn It can also mask symptoms, and they sometimes resume upon discontinuation.Шаблон:Sfn Dexamethasone's prevention of angiogenesis may explain why it treats HACE well.Шаблон:Sfn Three studies that examined how mice and rat brains react to hypoxia gave some credence to this idea.Шаблон:Sfn Шаблон:Sfn

If available, supplemental oxygen can be used as an adjunctive therapy, or when descent is not possible. FiO2 should be titrated to maintain arterial oxygen saturation of greater than 90%, bearing in mind that oxygen supply is often limited in high altitude clinics/environments.^[1]

In addition to oxygen therapy, a portable hyperbaric chamber (Gamow bag) can by used as a temporary measure in the treatment of HACE. These devices simulate a decrease in altitude of up to 7000 ft, but they are resource intensive and symptoms will often return after discontinuation of the device. Portable hyperbaric chambers should not be used in place of descent or evacuation to definitive care.^[2]

Diuretics may be helpful, but pose risks outside of a hospital environment.Шаблон:Sfn Sildenafil and tadalafil may help HACE,Шаблон:Sfn but there is little evidence of their efficacy.Шаблон:Sfn Theophylline is also theorized to help the condition.Шаблон:Sfn

Although AMS is not life-threatening,Шаблон:Sfn HACE is usually fatal within 24 hours if untreated.Шаблон:Sfn Without treatment, the patient will enter a comaШаблон:Sfn and then die.Шаблон:Sfn In some cases, patients have died within a few hours, and a few have survived for two days.Шаблон:Sfn Descriptions of fatal cases often involve climbers who continue ascending while experiencing the condition's symptoms.Шаблон:Sfn

Prognosis

Recovery varies between days and weeks,Шаблон:Sfn but most recover in a few days.Шаблон:Sfn After the condition is successfully treated, it is possible for climbers to reascend. Dexamethesone should be discontinued, but continual acetazolamide is recommended.Шаблон:Sfn In one study, it took patients between one week and one month to display a normal CT scan following HACE.Шаблон:Sfn

Epidemiology

HACE occurs in 0.5% to 1% of people who climb or trek between Шаблон:Convert and Шаблон:Convert.Шаблон:Sfn In some unusual cases, up to 30% of members of expeditions have had the condition.Шаблон:Sfn The condition is seldom seen below Шаблон:Convert,Шаблон:Sfn but in some rare cases it has developed as low as Шаблон:Convert.Шаблон:Sfn The condition generally does not occur until an individual has spent 48 hours at an altitude of Шаблон:Convert.Шаблон:Sfn

History

HACE was first described by a medical officer stationed in Chile in 1913, but few took note of it.Шаблон:Sfn Шаблон:Sfn Later, access to air travel made the condition more common because it allowed more people access to high mountains, such as those in the Himalayas.Шаблон:Sfn One early description of HACE may have been published in 1969 after a group of Indian soldiers made a rapid ascent to almost Шаблон:Convert.Шаблон:Sfn It is not definitely established whether they had HACE or acute decompression sickness.Шаблон:Sfn MRI has been used to study the effects of high altitude on the brain,Шаблон:Sfn providing the best evidence about the condition.Шаблон:Sfn A 1998 MRI study of nine climbers with HACE clearly demonstrated vasogenic edema.Шаблон:Sfn

Data about HACE are lacking because it generally occurs in remote areas, far from hospitalsШаблон:Sfn and is generally rare.Шаблон:Sfn It is uncommon for doctors to be able to study victims within six days of the condition's development.Шаблон:Sfn Animal models of HACE have not been developed.Шаблон:Sfn Several genes are being examined for the role they may play in the development of the condition.Шаблон:Sfn

Increased education and helicopter capabilities have combined to cut the number of deaths from the condition.Шаблон:Sfn Symptoms of HACE have been reported in many cases of deaths while descending Mount Everest, although HACE may not be the only problem they experienced.Шаблон:Sfn HACE also posed a threat to workers on the Qinghai–Tibet Railway.Шаблон:Sfn

References

Шаблон:Reflist

Bibliography

External links

Шаблон:Medical resources

[1] Шаблон:Cite journal

[2] Шаблон:Cite journal

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